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KMID : 0363819990330040398
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Korean Journal of Nuclear Medicine
1999 Volume.33 No. 4 p.398 ~ p.404
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Is the Renal Uptake of 99mTc-DMSA Decreased in Microalbuminuric Diabetic Patient?
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Kim Seong-Jang
Kim In-Ju
Kim Yong-Ki
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Abstract
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Purpose: Diabetic nephropathy is the most common cause of end stage renal disease and the incidence is progressively increasing. The aim of this study was to investigate the differences of -DMSA renal uptake among diabetic patients with normoalbuminuria, microalbuminuria and overt proteinuria, and then to determine the clinical usefulness of -DMSA in predicting early diabetic nephropathy
Materials and Methods: -DMSA scan was performed and a total renal uptake of -DMSA was measured in 145 diabetic patients. Patients were divided into 3 groups according to the amount of 24 hour urinary albumin excretion as Group I (normoalbuminuria, 74 cases), Group II (microalbuminuria, 39 cases), and Group III (overt proteinuria, 32 cases). The differences of -DMSA renal uptake among the 3 groups and the correlation between the renal uptake of -DMSA and other clinical parameters were analyzed.
Results: The total renal uptake of -DMSA of Group II () was significantly lower than that of Group I (, p<0.001). The uptake of Group III () was significantly lower than those of both Group I and Group II (p<0.001). -DMSA total renal uptakes correlated negatively with serum creatinine level (r=-0.629, p<0.001) and positively correlated with creatinine clearance rate (r=0.102, p<0.001).
Conclusion: -DMSA total renal uptake of diabetic patients with microalbuminuria was significantly decreased compared with that of patients of normoalbuminuria. Therefore, -DMSA scan can be used as a diagnostic study for early detection of the diabetic nephropathy.
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KEYWORD
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Diabetic nephropathy, Microalbuminuria, Tc-99m DMSA
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